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Liver

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LIVER

OVER VIEW

Cholesterol Synthesis

Overall the fat in the body is managed by the liver. Once the liver is full of glycogen, the liver starts converting glycogen into fat which is then transported to the rest of the body via the blood.

Hormones and Enzymes Productions

It produces blood clotting factors, proteins, and enzymes, helps maintain hormone balances

Deactivation of Toxic/Poison

The liver metabolises and detoxifies drugs and substances that are harmful to the body.

Bile Production

The liver secretes bile juice into the intestine which helps in dissolving fat and other nutrients from food.

Warehouse of Glucose

It serves as a warehouse of glucose inside the body.

When there is less(LOW) glucose in the body it converts glycogen back into glucose.

When there is excess(HIGH) glucose in the body it converts glucose into glycogen bundles and stores it.

Stores Critical Vitamins

The liver serves as a storage house for many critical vitamins like A, D, E, K and B12

 
LIVER

SYMPTOMS

Dark urine

Dark urine, because of bilirubin excreted through the kidneys

Yellow EYES and SKIN (Jaundice)

Jaundice, a yellow tint to the skin or eyes caused by an excess of bilirubin

Pale stool colour

Pale stool color, if the liver is not producing enough bile or if the flow of bile is blocked

Loss of appetite

Loss of appetite which may lead to weight loss

Nausea, Vomiting, Diarrhea

Abdominal pain and swelling

Abdominal pain, located on the right side of the body, beneath the ribs

Unexplained weight loss or gain

Itchy Skin

Itchy Skin, when normal liver function decreases

 
LIVER

DIAGNOSIS

How is Liver disease diagnosed?

There are various tests used to diagnose various liver diseases.

Liver Function Test

It is a group of tests that are performed together to detect, evaluate, and monitor liver disease or damage. The panel usually consists of several tests that are run at the same time on a blood sample. These typically include:

Alanine Aminotransferase (ALT)

An enzyme found mainly in liver tissue and to a lesser extent in the heart, kidney and skeletal muscle. It's measurement is clinically useful in the diagnosis of liver and biliary disease.

Aspartate Aminotransferase (AST)

An enzyme found in several parts of the body, including the heart, liver, and muscles. Since AST levels aren't as specific for liver damage as ALT, it's usually measured together with ALT to check for liver problems. When the liver is damaged, AST can be released into the blood stream. A high result on an AST test might indicate a problem with the liver or muscles.

Gamma Glutamyl Transpeptidase (GGTP) An enzyme that is found in many organs throughout the body, with the highest concentrations found in the liver. GGT is elevated in the blood in most diseases that cause damage to the liver or bile ducts.

Bilirubin, Total

It is used to detect an increased level of bilirubin in the blood. It helps to determine the cause of jaundice and diagnose conditions such as liver disease, haemolytic anaemia, and blockage of the bile ducts.

Bilirubin, Direct

It measures a form of bilirubin that is conjugated (combined with another compound) in the liver; It is only increased in the case of liver disease.

Alkaline Phosphatase (ALP)

An enzyme related to the bile ducts but also produced by the bones, intestines, and during pregnancy by the placenta (after birth).

High levels of ALP may indicate liver inflammation, blockage of the bile ducts, or bone disease.

Albumin

Albumin is the main protein made by the liver. This test measures the level of albumin in the blood. Alow result indicates that the liver isnt functioning properly.

Total Protein

The total protein test measures the total amount of protein in the blood and specifically looks for the amount of albumin and globulin. It also measures the ratio of albumin to globulin in the blood known as the A/G ratio.

Total Protein is useful in evaluating patients for nutritional status, liver disease, protein losing renal and gastrointestinal diseases.

Ammonia Test

Ammonia Test is used to detect an elevated level of ammonia in the blood that may be caused by severe liver disease, kidney failure, or certain rare genetic disorders.

Ceruloplasmin Test

Ceruloplasmin is the major copper-carrying protein in the blood, and also plays a role in iron metabolism. Ceruloplasmin testing is used to help diagnose Wilson disease, an autosomal recessive disorder. Low levels may also occur in Menkes syndrome which is a genetic defect in copper absorption.

Bile Acids, Total

Increases in serum bile acids may be a marker for acute hepatitis, chronic hepatitis, liver sclerosis, liver cancer, and intrahepatic cholestasis of pregnancy.

NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score

It is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver.

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